Brock Purdy passed for 325 yards and two touchdowns, Isaac Guerendo ran for two scores and Leonard Floyd registered two sacks against his former team as the host San Francisco 49ers routed the skidding Chicago Bears 38-13 on Sunday in Santa Clara, Calif.

San Francisco (6-7) stopped a three-game losing streak while remaining in the hunt in the NFC wild-card race.

Chicago lost its seventh in a row, stumbling through its first game under interim coach Thomas Brown, who took the reins after the organization fired third-year coach Matt Eberflus on Nov. 29. The Bears (4-9) were outgained 452-162.

The 49ers reached the end zone on three of their first four possessions and scored on four of their five first-half drives overall, excluding their kneel-down on the final play.

San Francisco raced down the field with the opening kickoff, needing just five plays and 2:40 of clock time to drive 70 yards for a touchdown. Purdy punctuated the drive with a seven-yard TD pass to Jauan Jennings, who also caught a 16-yard scoring pass to make it 21-0 with 7:41 left in the second quarter.

Seeing an increased workload with fellow running backs Christian McCaffrey and Jordan Mason on injured reserve, Guerendo scored the first of his two TDs with 1:39 left in the first quarter for a 14-0 lead.

Bears rookie quarterback Caleb Williams regrouped from an abysmal first half in which he was 6-for-9 for 27 yards. With the three sacks Chicago allowed before intermission, however, Chicago gained just four first-half yards.

The Bears got on the scoreboard on the first possession of the third quarter, with Williams capping a 16-play, 70-yard drive that took 9:04 of clock time with a 4-yard TD pass to Rome Odunze.

Odunze also caught a 14-yard scoring pass from Williams with 11:48 to go.

Guerendo rushed 15 times for 78 yards and scored his second touchdown from 4 yards out on the first play of the fourth quarter to make it 31-6. He also had 50 receiving yards before leaving with a foot injury in the fourth quarter.

Patrick Taylor Jr. capped the scoring with a 3-yard run.

Purdy was 20-for-25 through the air. George Kittle had six catches for 151 yards and Jennings had seven receptions for 90 yards.

Williams was 17-for-23 for 134 yards and two TDs. DJ Moore had six catches for 49 yards.

--Field Level Media